Histamine complex dating
designed, characterized and screened the constructs, purified the receptor, and prepared the manuscript.
collected the data and processed diffraction data with G.
were responsible for the overall project strategy and management and wrote the manuscript. The common antihistamines are antagonists of histamine H1 receptor (H1R), a G-protein-coupled receptor (GPCR) that is expressed in various tissues including airway, intestinal smooth muscle and brain. expressed the receptor, prepared the membrane, and performed the ligand-binding assay. performed flexible ligand-receptor docking, and prepared the manuscript. I.), Japan; the NIH Common Fund grant P50 GM073197 for technology development (R.
S.), the Mochida Memorial Foundation for Medical and Pharmaceutical Research (T.
A part of the work was performed in the Membrane Protein Laboratory funded by the Wellcome Trust (grant 062164/ Z/00/Z) at the Diamond Light Source Limited and at The Scripps Research Institute.